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Stomach cancer Pooling (StoP) Project
Financing Institutions:
Ref:
Principal researcher: Nuno Lunet
Research Team:
Participating Institutions: Department of Epidemiology, IRCCS – Istituto di Ricerche Farmacologiche Mario Negri, Milan, Italy Department of Clinical Sciences and Community Health, University of Milan, Milan, Italy Section of Hygiene, Institute of Public Health, Università Cattolica del Sacro Cuore, Rome, Italy IRCCS San Raffaele Pisana, Rome, Italy Institute of Public Health, University of Porto (ISPUP), Porto, Portugal Department of Clinical Epidemiology, Predictive Medicine and Public Health, University of Porto Medical School, Porto, Portugal Department of Epidemiology, UCLA Fielding School of Public Health and Jonsson Comprehensive Cancer Center, Los Angeles, California, USA The Tisch Cancer Institute and Institute for Translational Epidemiology, Mount Sinai School of Medicine, New York, USA Memorial Sloan Kettering Cancer Centre, Rockville Centre, USA Department of Social and Preventive Medicine, School of Public Health and Health Professions, University of Buffalo, Buffalo, New York, USA Department of Epidemiology, Harvard School of Public Health, Boston, Massachusetts, USA Penn State College of Medicine, Hershey, Pennsylvania, USA Cancer Epidemiology Unit, Institute of Social and Preventive Medicine (IUMSP), Lausanne University Hospital, Lausanne, Switzerland Department of Preventive Medicine, Kyushu University Faculty of Medical Sciences, Fukuoka, Japan Division of Epidemiology and Prevention, Aichi Cancer Center Research Institute, Nagoya, Japan Science Integration Division, Social Determinants and Science Integration Directorate, Public Health Agency of Canada, Canada Department of Epidemiology and Community Health, University of Ottawa, Ottawa, Ontario, Canada Aboriginal and Global Health Research Group, Department of Medicine, University of Alberta, Edmonton, Alberta, Canada Digestive Oncology Research Center, Digestive Disease Research Institute, Tehran Universities of Medical Sciences, Tehran Department of Community Medicine, Ardabil University of Medical Sciences, Ardabil, Iran Institute of Cardiovascular & Medical Sciences, University of Glasgow, Glasgow, UK Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden Unit of Nutritional Epidemiology, Institute of Environmental Medicine, Karolinska Institutet, Stockholm, Sweden Department of Epidemiology and Prevention, Russian N.N. Blokhin Cancer Research Center, Moscow, Russia Environmental and Cancer Epidemiology Unit, National Center of Epidemiology, Instituto de Salud Carlos III, Madrid, Spain CIBER Epidemiología y Salud Pública (CIBERESP), Madrid, Spain IIS Puerta de Hierro, Majadahonda, Spain Universidad de León, León, Spain Department of Hygiene, Epidemiology, and Medical Statistics, University of Athens Medical School, Athens, Greece Bureau of Epidemiologic Research, Academy of Athens, Athens, Greece Medical Informatics Center, Peking University, China
Start date: 2013-06-11
End date: 2015-07-01
Summary:
Team:
Claudio Pelucchi, Nuno Lunet, Stefania Boccia, Zuo-Feng Zhang, Delphine Prauda, Paolo Boffetta, Fabio Levi, Keitaro Matsuo, Hidemi Ito, Jinfu Hu, Kenneth C. Johnson, Monica Ferraroni, Guo-Pei Yu, Bárbara Peleteiro, Reza Malekzadeh, Mohammad H. Derakhshan, Weimin Ye, David Zaridze, Dmitry Maximovitch, Nuria Aragonés, Vicente Martínz, Mohammadreza Pakseresht, Farhad Pourfarzi, Andrea Bellavia, Nicola Orsini, Alicja Wolk, Lina Mu, Dario Arzani, Robert C. Kurtz, Pagona Lagiou, Dimitrios Trichopoulos, Joshua Muscat, Carlo La Vecchia, Eva Negri.

The "Stomach cancer Pooling (StoP) Project" is a consortium of epidemiological studies on gastric cancer, which relies on the presence of Portugal, similar to what already happens with other neoplasms. This new project aims to examine the role of several lifestyle and genetic determinants in the etiology of gastric cancer through pooled analyses of individual-level data, after central collection and validation of the original data sets by an Italian research group.
Until now, 22 studies from 11 countries agreed to participate (Canada, China, Spain, USA, Greece, Iran, Italy, Japan, Portugal, Russia and Sweden), for a total of over 9000 cases and 23,000 controls. Of cases, 40% are from Asia, 43% from Europe and 17% from North America; 34% are women and 66% men; median age is 61 years.
The uniquely large dataset will allow to define and quantify the main effects of each risk factor of interest, including a number of infrequent habits, and to adequately address associations in subgroups of the population, as well as interaction within and between environmental and genetic factors. Further, separate analyses according to different histotypes and subsites of gastric cancer will be conducted, in order to identify potential different risk patterns and aetiological characteristics. 

This project is supported by the Italian Ministry of Health (Bando Giovani Ricercatori 2011–2012).





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